The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype

BACKGROUND: Increased activation of mammalian target of rapamycin (mTOR) is observed in numerous human cancers. Recent studies on the glioma kinome have identified several deregulated pathways that converge and activate mTOR. The available evidence on the role of microglia in CNS cancers would sugge...

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Detalles Bibliográficos
Autores principales: Lisi, Lucia, Laudati, Emilia, Navarra, Pierluigi, Dello Russo, Cinzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128534/
https://www.ncbi.nlm.nih.gov/pubmed/25051975
http://dx.doi.org/10.1186/1742-2094-11-125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128534/
https://www.ncbi.nlm.nih.gov/pubmed/25051975
http://dx.doi.org/10.1186/1742-2094-11-125

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