Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness

“Pre-leukemic” mutations are thought to promote clonal expansion of haematopoietic stem cells (HSCs) by increasing self-renewal and competitiveness(1); however, mutations that increase HSC proliferation tend to reduce competitiveness and self-renewal potential, raising the question of how a mutant H...

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Detalles Bibliográficos
Autores principales: Li, Qing, Bohin, Natacha, Wen, Tiffany, Ng, Victor, Magee, Jeffrey, Chen, Shann-Ching, Shannon, Kevin, Morrison, Sean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128640/
https://www.ncbi.nlm.nih.gov/pubmed/24284627
http://dx.doi.org/10.1038/nature12830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128640/
https://www.ncbi.nlm.nih.gov/pubmed/24284627
http://dx.doi.org/10.1038/nature12830

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