Cargando…
Inhibition of CSF-1R Supports T-Cell Mediated Melanoma Therapy
Tumor associated macrophages (TAM) can promote angiogenesis, invasiveness and immunosuppression. The cytokine CSF-1 (or M-CSF) is an important factor of TAM recruitment and differentiation and several pharmacological agents targeting the CSF-1 receptor (CSF-1R) have been developed to regulate TAM in...
Autores principales: | Sluijter, Marjolein, van der Sluis, Tetje C., van der Velden, Pieter A., Versluis, Mieke, West, Brian L., van der Burg, Sjoerd H., van Hall, Thorbald |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128661/ https://www.ncbi.nlm.nih.gov/pubmed/25110953 http://dx.doi.org/10.1371/journal.pone.0104230 |
Ejemplares similares
-
Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma
por: de Lange, Mark J., et al.
Publicado: (2015) -
Synergy between chemotherapy and cancer vaccination
por: van der Sluis, Tetje C., et al.
Publicado: (2015) -
T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy
por: Doorduijn, Elien M., et al.
Publicado: (2017) -
Interleukin‐6‐mediated resistance to immunotherapy is linked to impaired myeloid cell function
por: Beyranvand Nejad, Elham, et al.
Publicado: (2020) -
Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling
por: Marijt, Koen A., et al.
Publicado: (2019)