Enhanced Anti-Tumor Effect of Zoledronic Acid Combined with Temozolomide against Human Malignant Glioma Cell Expressing O(6)-Methylguanine DNA Methyltransferase

Temozolomide (TMZ), a DNA methylating agent, is widely used in the adjuvant treatment of malignant gliomas. O(6)-methylguanine-DNA methyltranferase (MGMT), a DNA repair enzyme, is frequently discussed as the main factor that limits the efficacy of TMZ. Zoledronic acid (ZOL), which is clinically appl...

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Detalles Bibliográficos
Autores principales: Fukai, Junya, Koizumi, Fumiaki, Nakao, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128678/
https://www.ncbi.nlm.nih.gov/pubmed/25111384
http://dx.doi.org/10.1371/journal.pone.0104538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128678/
https://www.ncbi.nlm.nih.gov/pubmed/25111384
http://dx.doi.org/10.1371/journal.pone.0104538

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