A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2

Lipoxygenase (LOX) enzymes catalyze the hydroperoxidation of arachidonic acid and other polyunsaturated fatty acids to hydroxyeicosatetraenoic acids with varying positional specificity to yield important biological signaling molecules. Human epithelial 15­lipoxygenase­2 (15-LOX-2) is a highly specif...

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Detalles Bibliográficos
Autores principales: Jameson, J. Brian, Kantz, Auric, Schultz, Lena, Kalyanaraman, Chakrapani, Jacobson, Matthew P., Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Holman, Theodore R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128814/
https://www.ncbi.nlm.nih.gov/pubmed/25111178
http://dx.doi.org/10.1371/journal.pone.0104094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128814/
https://www.ncbi.nlm.nih.gov/pubmed/25111178
http://dx.doi.org/10.1371/journal.pone.0104094

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