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A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2

Lipoxygenase (LOX) enzymes catalyze the hydroperoxidation of arachidonic acid and other polyunsaturated fatty acids to hydroxyeicosatetraenoic acids with varying positional specificity to yield important biological signaling molecules. Human epithelial 15lipoxygenase2 (15-LOX-2) is a highly specif...

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Detalles Bibliográficos
Autores principales:	Jameson, J. Brian, Kantz, Auric, Schultz, Lena, Kalyanaraman, Chakrapani, Jacobson, Matthew P., Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Holman, Theodore R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128814/ https://www.ncbi.nlm.nih.gov/pubmed/25111178 http://dx.doi.org/10.1371/journal.pone.0104094

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