Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes

Protein kinase C related kinase 1 (PRK1) is a component of Rho-GTPase, androgen receptor, histone demethylase and histone deacetylase signaling pathways implicated in prostate and ovarian cancer. Herein we describe the crystal structure of PRK1 in apo form, and also in complex with a panel of litera...

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Detalles Bibliográficos
Autores principales: Chamberlain, Philip, Delker, Silvia, Pagarigan, Barbra, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Muir, Jeff, Raheja, Neil, Cathers, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128815/
https://www.ncbi.nlm.nih.gov/pubmed/25111382
http://dx.doi.org/10.1371/journal.pone.0103638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128815/
https://www.ncbi.nlm.nih.gov/pubmed/25111382
http://dx.doi.org/10.1371/journal.pone.0103638

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