Agonist-bound structure of the human P2Y(12) receptor

The P2Y(12) receptor (P2Y(12)R), one of eight members of the P2YR family expressed in humans, has been identified as one of the most prominent clinical drug targets for inhibition of platelet aggregation. Consequently, extensive mutagenesis and modeling studies of the P2Y(12)R have revealed many asp...

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Detalles Bibliográficos
Autores principales: Zhang, Jin, Zhang, Kaihua, Gao, Zhan-Guo, Paoletta, Silvia, Zhang, Dandan, Han, Gye Won, Li, Tingting, Ma, Limin, Zhang, Wenru, Müller, Christa E., Yang, Huaiyu, Jiang, Hualiang, Cherezov, Vadim, Katritch, Vsevolod, Jacobson, Kenneth A., Stevens, Raymond C., Wu, Beili, Zhao, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128917/
https://www.ncbi.nlm.nih.gov/pubmed/24784220
http://dx.doi.org/10.1038/nature13288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128917/
https://www.ncbi.nlm.nih.gov/pubmed/24784220
http://dx.doi.org/10.1038/nature13288

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