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Rotenone Remarkably Attenuates Oxidative Stress, Inflammation, and Fibrosis in Chronic Obstructive Uropathy

Mitochondrial abnormality has been shown in many kidney disease models. However, its role in the pathogenesis of chronic kidney diseases (CKDs) is still uncertain. In present study, a mitochondrial complex I inhibitor rotenone was applied to the mice subjected to unilateral ureteral obstruction (UUO...

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Detalles Bibliográficos
Autores principales: Sun, Ying, Zhang, Yue, Zhao, Daqiang, Ding, Guixia, Huang, Songming, Zhang, Aihua, Jia, Zhanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130131/
https://www.ncbi.nlm.nih.gov/pubmed/25140114
http://dx.doi.org/10.1155/2014/670106