Arsenic Trioxide Reactivates Proteasome-Dependent Degradation of Mutant p53 Protein in Cancer Cells in Part via Enhanced Expression of Pirh2 E3 Ligase

The p53 gene is mutated in more than 50% of human tumors. Mutant p53 exerts an oncogenic function and is often highly expressed in cancer cells due to evasion of proteasome-dependent degradation. Thus, reactivating proteasome-dependent degradation of mutant p53 protein is an attractive strategy for...

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Detalles Bibliográficos
Autores principales: Yan, Wensheng, Jung, Yong-Sam, Zhang, Yanhong, Chen, Xinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130519/
https://www.ncbi.nlm.nih.gov/pubmed/25116336
http://dx.doi.org/10.1371/journal.pone.0103497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130519/
https://www.ncbi.nlm.nih.gov/pubmed/25116336
http://dx.doi.org/10.1371/journal.pone.0103497

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