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Targeting Catalase but Not Peroxiredoxins Enhances Arsenic Trioxide-Induced Apoptosis in K562 Cells
Despite considerable efficacy of arsenic trioxide (As(2)O(3)) in acute promyelocytic leukemia (APL) treatment, other non-APL leukemias, such as chronic myeloid leukemia (CML), are less sensitive to As(2)O(3) treatment. However, the underlying mechanism is not well understood. Here we show that relat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130628/ https://www.ncbi.nlm.nih.gov/pubmed/25115845 http://dx.doi.org/10.1371/journal.pone.0104985 |