Celastrol Inhibits Lung Infiltration in Differential Syndrome Animal Models by Reducing TNF-α and ICAM-1 Levels while Preserving Differentiation in ATRA-Induced Acute Promyelocytic Leukemia Cells

All-trans retinoic acid (ATRA) is a revolutionary agent for acute promyelocytic leukemia (APL) treatment via differentiation induction. However, ATRA treatment also increases cytokine, chemokine, and adhesive molecule (mainly ICAM-1) expression, which can cause clinical complications, including a se...

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Detalles Bibliográficos
Autores principales: Xu, Li-min, Zheng, Yue-juan, Wang, Ying, Yang, Yang, Cao, Fan-fan, Peng, Bin, Xu, Xiong-fei, An, Hua-zhang, Zheng, Ao-xiang, Zhang, Deng-hai, Uzan, Georges, Yu, Yi-zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130635/
https://www.ncbi.nlm.nih.gov/pubmed/25116125
http://dx.doi.org/10.1371/journal.pone.0105131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130635/
https://www.ncbi.nlm.nih.gov/pubmed/25116125
http://dx.doi.org/10.1371/journal.pone.0105131

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