A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival

Given the importance of deregulated phosphoinositide (PI) signaling in leukemic hematopoiesis, genes coding for proteins that regulate PI metabolism may have significant and as yet unappreciated roles in leukemia. We performed a targeted knockdown screen of PI modulator genes in human AML cells and...

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Detalles Bibliográficos
Autores principales: Jude, Julian G, Spencer, Gary J, Huang, Xu, Somerville, Tim D D, Jones, David R, Divecha, Nullin, Somervaille, Tim C P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130659/
https://www.ncbi.nlm.nih.gov/pubmed/24681948
http://dx.doi.org/10.1038/onc.2014.77

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130659/
https://www.ncbi.nlm.nih.gov/pubmed/24681948
http://dx.doi.org/10.1038/onc.2014.77

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