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Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis
The restoration of p53 tumor suppressor function is a promising therapeutic strategy to combat cancer. However, the biological outcomes of p53 activation, ranging from the promotion of growth arrest to the induction of cell death, are hard to predict, which limits the clinical application of p53-bas...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131181/ https://www.ncbi.nlm.nih.gov/pubmed/24971482 http://dx.doi.org/10.1038/cdd.2014.69 |