Protein delivery into live cells by incubation with an endosomolytic agent

We report on how a dimer of the cell-penetrating peptide TAT, dfTAT, penetrates live cells by escaping from endosomes with a particularly high efficiency. By mediating endosomal leakage, dfTAT also delivers proteins into cultured cells after a simple co-incubation procedure. Cytosolic delivery is ac...

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Detalles Bibliográficos
Autores principales: Erazo-Oliveras, Alfredo, Najjar, Kristina, Dayani, Laila, Wang, Ting-Yi, Johnson, Gregory A., Pellois, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131206/
https://www.ncbi.nlm.nih.gov/pubmed/24930129
http://dx.doi.org/10.1038/nmeth.2998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131206/
https://www.ncbi.nlm.nih.gov/pubmed/24930129
http://dx.doi.org/10.1038/nmeth.2998

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