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Single chromosome transcriptional profiling reveals chromosome-level regulation of gene expression
Here we report iceFISH, a multiplex imaging method for measuring gene expression and chromosome structure simultaneously on single chromosomes. We demonstrate that chromosomal translocations can alter transcription chromosome-wide, finding substantial differences in transcriptional frequency between...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131260/ https://www.ncbi.nlm.nih.gov/pubmed/23416756 http://dx.doi.org/10.1038/nmeth.2372 |