Silymarin Inhibits Cytokine-Stimulated Pancreatic Beta Cells by Blocking the ERK1/2 Pathway

We show that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibits cytokine mixture (CM: TNF-α, IFN-γ, and IL-1β)-induced production of nitric oxide (NO) in the pancreatic beta cell line MIN6N8a. Immunostaining and Western blot analysis showed that silymarin inh...

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Detalles Bibliográficos
Autores principales: Kim, Eun Jeong, Kim, Jeeho, Lee, Min Young, Sudhanva, Muddenahalli Srinivasa, Devakumar, Sundaravinayagam, Jeon, Young Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131525/
https://www.ncbi.nlm.nih.gov/pubmed/25143805
http://dx.doi.org/10.4062/biomolther.2014.072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131525/
https://www.ncbi.nlm.nih.gov/pubmed/25143805
http://dx.doi.org/10.4062/biomolther.2014.072

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