Inhibition of P-glycoprotein by two artemisinin derivatives

P-Glycoprotein/MDR1 represents an important component of the blood brain barrier and contributes to multidrug resistance. We investigated two derivatives of the anti-malarial artemisinin, SM616 and GHP-AJM-3/23, concerning their ability to interact with P-glycoprotein. The ability of the two compoun...

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Detalles Bibliográficos
Autores principales: Steglich, Babette, Mahringer, Anne, Li, Ying, Posner, Gary H., Fricker, Gert, Efferth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2012
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131583/
http://dx.doi.org/10.1007/s13659-012-0006-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131583/
http://dx.doi.org/10.1007/s13659-012-0006-3

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