Two Acidic, Anticoagulant PLA(2) Isoenzymes Purified from the Venom of Monocled Cobra Naja kaouthia Exhibit Different Potency to Inhibit Thrombin and Factor Xa via Phospholipids Independent, Non-Enzymatic Mechanism

BACKGROUND: The monocled cobra (Naja kaouthia) is responsible for snakebite fatality in Indian subcontinent and in south-western China. Phospholipase A(2) (PLA(2); EC 3.1.1.4) is one of the toxic components of snake venom. The present study explores the mechanism and rationale(s) for the differences...

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Detalles Bibliográficos
Autores principales: Mukherjee, Ashis K., Kalita, Bhargab, Thakur, Rupamoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131862/
https://www.ncbi.nlm.nih.gov/pubmed/25118676
http://dx.doi.org/10.1371/journal.pone.0101334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131862/
https://www.ncbi.nlm.nih.gov/pubmed/25118676
http://dx.doi.org/10.1371/journal.pone.0101334

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