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Fluctuations of an Exposed π-Helix Involved in Lipoxygenase Substrate Recognition

[Image: see text] The second helix in lipoxygenases adapts to permit substrate access to the active site, but details of this process are varied and poorly understood. We therefore examined the dynamics of helix 2 in solutions of spin-labeled soybean lipoxygenase-1 and spin relaxation at 60 K of the...

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Detalles Bibliográficos
Autores principales: Bradshaw, Miles D., Gaffney, Betty J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131896/
https://www.ncbi.nlm.nih.gov/pubmed/25036469
http://dx.doi.org/10.1021/bi500768c