The DNA Binding Property of PML/RARA but Not the Integrity of PML Nuclear Bodies Is Indispensable for Leukemic Transformation

PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL). It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block and malignant transformation of hematopoietic cells. Here, we found that mice primary hematopoietic prog...

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Detalles Bibliográficos
Autores principales: Liu, Xi, Yuan, Hao, Peres, Laurent, Chen, Saijuan, Chen, Zhu, de The, Hugues, Zhou, Jun, Zhu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131979/
https://www.ncbi.nlm.nih.gov/pubmed/25119106
http://dx.doi.org/10.1371/journal.pone.0104906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131979/
https://www.ncbi.nlm.nih.gov/pubmed/25119106
http://dx.doi.org/10.1371/journal.pone.0104906

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