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The DNA Binding Property of PML/RARA but Not the Integrity of PML Nuclear Bodies Is Indispensable for Leukemic Transformation
PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL). It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block and malignant transformation of hematopoietic cells. Here, we found that mice primary hematopoietic prog...
Autores principales: | Liu, Xi, Yuan, Hao, Peres, Laurent, Chen, Saijuan, Chen, Zhu, de The, Hugues, Zhou, Jun, Zhu, Jun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131979/ https://www.ncbi.nlm.nih.gov/pubmed/25119106 http://dx.doi.org/10.1371/journal.pone.0104906 |
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