Engineered Hyperactive Integrase for Concerted HIV-1 DNA Integration

The DNA cutting and joining reactions of HIV-1 integration are catalyzed by integrase (IN), a viral protein that functions as a tetramer bridging the two viral DNA ends (intasome). Two major obstacles for biochemical and structural studies of HIV-1 intasomes are 1) the low efficiency of assembly wit...

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Detalles Bibliográficos
Autores principales: Li, Min, Jurado, Kellie A., Lin, Shiqiang, Engelman, Alan, Craigie, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132020/
https://www.ncbi.nlm.nih.gov/pubmed/25119883
http://dx.doi.org/10.1371/journal.pone.0105078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132020/
https://www.ncbi.nlm.nih.gov/pubmed/25119883
http://dx.doi.org/10.1371/journal.pone.0105078

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