Generation of Ugt1-Deficient Murine Liver Cell Lines Using TALEN Technology

The Crigler-Najjar Syndrome Type I (CNSI) is a rare genetic disorder caused by mutations in the Ugt1a1 gene. It is characterized by unconjugated hyperbilirubinemia that may result in severe neurologic damage and death if untreated. To date, liver transplantation is the only curative treatment. With...

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Detalles Bibliográficos
Autores principales: Porro, Fabiola, Bockor, Luka, De Caneva, Alessia, Bortolussi, Giulia, Muro, Andrés F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132024/
https://www.ncbi.nlm.nih.gov/pubmed/25118822
http://dx.doi.org/10.1371/journal.pone.0104816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132024/
https://www.ncbi.nlm.nih.gov/pubmed/25118822
http://dx.doi.org/10.1371/journal.pone.0104816

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