The Role of Nibrin in Doxorubicin-Induced Apoptosis and Cell Senescence in Nijmegen Breakage Syndrome Patients Lymphocytes

Nibrin plays an important role in the DNA damage response (DDR) and DNA repair. DDR is a crucial signaling pathway in apoptosis and senescence. To verify whether truncated nibrin (p70), causing Nijmegen Breakage Syndrome (NBS), is involved in DDR and cell fate upon DNA damage, we used two (S4 and S3...

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Detalles Bibliográficos
Autores principales: Alster, Olga, Bielak-Zmijewska, Anna, Mosieniak, Grazyna, Moreno-Villanueva, Maria, Dudka-Ruszkowska, Wioleta, Wojtala, Aleksandra, Kusio-Kobiałka, Monika, Korwek, Zbigniew, Burkle, Alexander, Piwocka, Katarzyna, Siwicki, Jan K., Sikora, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132076/
https://www.ncbi.nlm.nih.gov/pubmed/25119968
http://dx.doi.org/10.1371/journal.pone.0104964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132076/
https://www.ncbi.nlm.nih.gov/pubmed/25119968
http://dx.doi.org/10.1371/journal.pone.0104964

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