Structure Based Refinement of a Humanized Monoclonal Antibody That Targets Tumor Antigen Disialoganglioside GD2

Disialoganglioside GD2 is an important target on several pediatric and adult cancer types including neuroblastoma, retinoblastoma, melanoma, small-cell lung cancer, brain tumors, sarcomas, and cancer stem cells. We have utilized structural and computational methods to refine the framework of humaniz...

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Detalles Bibliográficos
Autores principales: Ahmed, Mahiuddin, Hu, Jian, Cheung, Nai-Kong V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132262/
https://www.ncbi.nlm.nih.gov/pubmed/25177320
http://dx.doi.org/10.3389/fimmu.2014.00372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132262/
https://www.ncbi.nlm.nih.gov/pubmed/25177320
http://dx.doi.org/10.3389/fimmu.2014.00372

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