Cargando…

MYC is essential for the formation and maintenance of germinal centers

Germinal centers (GC) are sites of intense B cell proliferation, central for T cell dependent antibody responses. However, the role of MYC, a key cell cycle regulator, in this process has been questioned. Here, we identified MYC positive B cell subpopulations in immature and mature GCs, and show thr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Calado, Dinis Pedro, Sasaki, Yoshiteru, Godinho, Susana A., Pellerin, Alex, Köchert, Karl, Sleckman, Barry P., de Alborán, Ignacio Moreno, Janz, Martin, Rodig, Scott, Rajewsky, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132664/ https://www.ncbi.nlm.nih.gov/pubmed/23001146 http://dx.doi.org/10.1038/ni.2418

Ejemplares similares

Burkitt lymphomagenesis linked to MYC plus PI3K in germinal center B cells
por: Sander, Sandrine, et al.
Publicado: (2012)

Positive Selection in the Light Zone of Germinal Centers
por: Nakagawa, Rinako, et al.
Publicado: (2021)

IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells
por: Pasparakis, Manolis, et al.
Publicado: (2002)

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma
por: D’Avola, Annalisa, et al.
Publicado: (2022)

Myc stimulates B lymphocyte differentiation and amplifies calcium signaling
por: Habib, Tania, et al.
Publicado: (2007)

PLC-γ2 is essential for formation and maintenance of memory B cells
por: Hikida, Masaki, et al.
Publicado: (2009)

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage
por: Toboso-Navasa, Amparo, et al.
Publicado: (2020)

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance
por: Thomas, Lance R., et al.
Publicado: (2019)

Myc proteins in brain tumor development and maintenance
por: Swartling, Fredrik J.
Publicado: (2012)

c-MYC is required for germinal center selection and cyclic re-entry
por: Dominguez-Sola, David, et al.
Publicado: (2012)

Somatic Mutation of the Cd95 Gene in Human B Cells as a Side-Effect of the Germinal Center Reaction
por: Müschen, Markus, et al.
Publicado: (2000)

α-Xylosidase plays essential roles in xyloglucan remodelling, maintenance of cell wall integrity, and seed germination in Arabidopsis thaliana
por: Shigeyama, Takuma, et al.
Publicado: (2016)

Components Essential for the Generation of Germinal Centers
por: Rizzo, L. V., et al.
Publicado: (1998)

Antiviral Protection and Germinal Center Formation, But Impaired B Cell Memory in the Absence of CD19
por: Fehr, Thomas, et al.
Publicado: (1998)

TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells
por: Schoeler, Katia, et al.
Publicado: (2019)

CIN85 drives B cell responses by linking BCR signals to the canonical NF-κB pathway
por: Kometani, Kohei, et al.
Publicado: (2011)

Germinal Centre B Cell Functions and Lymphomagenesis: Circuits Involving MYC and MicroRNAs
por: Robaina, Marcela Cristina, et al.
Publicado: (2019)

c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells
por: Wang, Jialiang, et al.
Publicado: (2008)

Glutathione synthesis is essential for pollen germination in vitro
por: Zechmann, Bernd, et al.
Publicado: (2011)

Investigation of potential traces of pluripotency in germinal-center-derived B-cell lymphomas driven by MYC
por: Wagener, R, et al.
Publicado: (2015)

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
por: Onoyama, Ichiro, et al.
Publicado: (2007)

Impairing the maintenance of germinative cells in Echinococcus multilocularis by targeting Aurora kinase
por: Cheng, Zhe, et al.
Publicado: (2019)

Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability
por: Schenten, Dominik, et al.
Publicado: (2009)

Exocyst subunit SEC3A marks the germination site and is essential for pollen germination in Arabidopsis thaliana
por: Li, Yan, et al.
Publicado: (2017)

The essential boat maintenance manual /
por: Toghill, Jeff
Publicado: (2001)

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation
por: Shi, Junwei, et al.
Publicado: (2013)

Tuberous sclerosis complex is required for tumor maintenance in MYC‐driven Burkitt's lymphoma
por: Hartleben, Götz, et al.
Publicado: (2018)

Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia
por: Zhu, Shouhai, et al.
Publicado: (2020)

The RNA-binding protein HuR is required for maintenance of the germinal centre response
por: Osma-Garcia, Ines C., et al.
Publicado: (2021)

Immunohistochemical Detection of MYC-driven Diffuse Large B-Cell Lymphomas
por: Kluk, Michael J., et al.
Publicado: (2012)

L-Myc expression by dendritic cells is required for optimal T-cell priming
por: Wumesh, KC, et al.
Publicado: (2014)

Allelopathic Effects of Essential Oils on Seed Germination of Barley and Wheat
por: Zheljazkov, Valtcho D., et al.
Publicado: (2021)

The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development
por: Benhamou, David, et al.
Publicado: (2018)

IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β
por: Waisman, Ari, et al.
Publicado: (2007)

Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells
por: Cousu, Clara, et al.
Publicado: (2023)

STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells
por: Yada, Yutaro, et al.
Publicado: (2023)

Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination
por: Wesemann, Duane R., et al.
Publicado: (2011)

Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms
por: Qi, Chen-Feng, et al.
Publicado: (2012)

The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphoma
por: Lacroix, Marion, et al.
Publicado: (2023)

The regulation of DNA end resection by chromatin response to DNA double strand breaks
por: Chen, Bo-Ruei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_obfp1k3peum7pid5r9hnvp83lq