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Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes
Deep mutational scanning has emerged as a promising tool for mapping sequence–activity relationships in proteins, ribonucleic acid and deoxyribonucleic acid. In this approach, diverse variants of a sequence of interest are first ranked according to their activities in a relevant assay, and this rank...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132701/ https://www.ncbi.nlm.nih.gov/pubmed/24914046 http://dx.doi.org/10.1093/nar/gku511 |