G-quadruplexes are specifically recognized and distinguished by selected designed ankyrin repeat proteins

We introduce designed ankyrin repeat binding proteins (DARPins) as a novel class of highly specific and structure-selective DNA-binding proteins, which can be functionally expressed within all cells. Human telomere quadruplex was used as target to select specific binders with ribosome display. The s...

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Detalles Bibliográficos
Autores principales: Scholz, Oliver, Hansen, Simon, Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132713/
https://www.ncbi.nlm.nih.gov/pubmed/25053846
http://dx.doi.org/10.1093/nar/gku571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132713/
https://www.ncbi.nlm.nih.gov/pubmed/25053846
http://dx.doi.org/10.1093/nar/gku571

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