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G-quadruplexes are specifically recognized and distinguished by selected designed ankyrin repeat proteins
We introduce designed ankyrin repeat binding proteins (DARPins) as a novel class of highly specific and structure-selective DNA-binding proteins, which can be functionally expressed within all cells. Human telomere quadruplex was used as target to select specific binders with ribosome display. The s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132713/ https://www.ncbi.nlm.nih.gov/pubmed/25053846 http://dx.doi.org/10.1093/nar/gku571 |