Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6

Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance pathway that recognizes mRNAs with premature stop codons and targets them for rapid degradation. Evidence from previous studies has converged on UPF1 as the central NMD factor. In human cells, the SMG1 kinase phosphorylates UPF1 at the...

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Detalles Bibliográficos
Autores principales: Chakrabarti, Sutapa, Bonneau, Fabien, Schüssler, Steffen, Eppinger, Elfriede, Conti, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132714/
https://www.ncbi.nlm.nih.gov/pubmed/25013172
http://dx.doi.org/10.1093/nar/gku578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132714/
https://www.ncbi.nlm.nih.gov/pubmed/25013172
http://dx.doi.org/10.1093/nar/gku578

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