Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease

[Image: see text] Under the selective pressure of therapy, HIV-1 protease mutants resistant to inhibitors evolve to confer drug resistance. Such mutations can impact both the dynamics and structures of the bound and unbound forms of the enzyme. Flap+ is a multidrug-resistant variant of HIV-1 proteas...

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Detalles Bibliográficos
Autores principales: Cai, Yufeng, Myint, Wazo, Paulsen, Janet L., Schiffer, Celia A., Ishima, Rieko, Kurt Yilmaz, Nese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132871/
https://www.ncbi.nlm.nih.gov/pubmed/25136270
http://dx.doi.org/10.1021/ct4010454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132871/
https://www.ncbi.nlm.nih.gov/pubmed/25136270
http://dx.doi.org/10.1021/ct4010454

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