Evidence for the Role of Active Site Residues in the Hairpin Ribozyme from Molecular Simulations along the Reaction Path

[Image: see text] The hairpin ribozyme accelerates a phosphoryl transfer reaction without catalytic participation of divalent metal ions. Residues A38 and G8 have been implicated as playing roles in general acid and base catalysis, respectively. Here we explore the structure and dynamics of key acti...

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Detalles Bibliográficos
Autores principales: Heldenbrand, Hugh, Janowski, Pawel A., Giambaşu, George, Giese, Timothy J., Wedekind, Joseph E., York, Darrin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132952/
https://www.ncbi.nlm.nih.gov/pubmed/24842535
http://dx.doi.org/10.1021/ja500180q

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132952/
https://www.ncbi.nlm.nih.gov/pubmed/24842535
http://dx.doi.org/10.1021/ja500180q

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