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Inhibition of the TRAIL Death Receptor by CMV Reveals Its Importance in NK Cell-Mediated Antiviral Defense

TNF-related apoptosis inducing ligand (TRAIL) death receptors (DR) regulate apoptosis and inflammation, but their role in antiviral defense is poorly understood. Cytomegaloviruses (CMV) encode many immune-modulatory genes that shape host immunity, and they utilize multiple strategies to target the T...

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Detalles Bibliográficos
Autores principales: Verma, Shilpi, Loewendorf, Andrea, Wang, Qiao, McDonald, Bryan, Redwood, Alec, Benedict, Chris A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133390/
https://www.ncbi.nlm.nih.gov/pubmed/25122141
http://dx.doi.org/10.1371/journal.ppat.1004268