The HIV-1 Envelope Transmembrane Domain Binds TLR2 through a Distinct Dimerization Motif and Inhibits TLR2-Mediated Responses

HIV-1 uses a number of means to manipulate the immune system, to avoid recognition and to highjack signaling pathways. HIV-1 infected cells show limited Toll-Like Receptor (TLR) responsiveness via as yet unknown mechanisms. Using biochemical and biophysical approaches, we demonstrate that the trans-...

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Detalles Bibliográficos
Autores principales: Reuven, Eliran Moshe, Ali, Mohammad, Rotem, Etai, Schwarzter, Roland, Gramatica, Andrea, Futerman, Anthony H., Shai, Yechiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133399/
https://www.ncbi.nlm.nih.gov/pubmed/25121610
http://dx.doi.org/10.1371/journal.ppat.1004248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133399/
https://www.ncbi.nlm.nih.gov/pubmed/25121610
http://dx.doi.org/10.1371/journal.ppat.1004248

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