An approach to trial design and analysis in the era of non-proportional hazards of the treatment effect

BACKGROUND: Most randomized controlled trials with a time-to-event outcome are designed and analysed under the proportional hazards assumption, with a target hazard ratio for the treatment effect in mind. However, the hazards may be non-proportional. We address how to design a trial under such condi...

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Detalles Bibliográficos
Autores principales: Royston, Patrick, Parmar, Mahesh KB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133607/
https://www.ncbi.nlm.nih.gov/pubmed/25098243
http://dx.doi.org/10.1186/1745-6215-15-314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133607/
https://www.ncbi.nlm.nih.gov/pubmed/25098243
http://dx.doi.org/10.1186/1745-6215-15-314

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