Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector

We used a lentiviral system for expressing secreted human Aβ in the brains of young and old APOE knock-in mice. This system allowed us to examine Aβ metabolism in vivo, and test the effects of both aging and APOE genotype, two of the strongest risk factors for Alzheimer’s disease. We injected the Aβ...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Wenjuan, Zhang, Jiguo, Davis, Elizabeth G., Rebeck, G. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133689/
https://www.ncbi.nlm.nih.gov/pubmed/25177293
http://dx.doi.org/10.3389/fnagi.2014.00210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133689/
https://www.ncbi.nlm.nih.gov/pubmed/25177293
http://dx.doi.org/10.3389/fnagi.2014.00210

Ejemplares similares