IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter

Activation induced CD154 expression on CD4 T cells is prolonged in systemic lupus erythematosus but the mechanism(s) for its dysregulation are unknown. The studies reported herein demonstrate that IL-15 is capable of prolonging CD154 expression on PHA activated CD4 T cells. Since IL-15 signals throu...

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Detalles Bibliográficos
Autores principales: Lowe, RM, Genin, A, Orgun, N, Cron, RQ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133980/
https://www.ncbi.nlm.nih.gov/pubmed/24500400
http://dx.doi.org/10.1038/gene.2014.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133980/
https://www.ncbi.nlm.nih.gov/pubmed/24500400
http://dx.doi.org/10.1038/gene.2014.3

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