Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii

OBJECTIVE: To test the activity of a small molecule compound that targets Lipid II against Acinetobacter baumannii. METHODS: Susceptibility to small molecule Lipid II inhibitor BAS00127538 was assessed using carbapenem- and colistin-resistant clinical isolates of A. baumannii. In addition, synergy b...

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Autor principal: de Leeuw, Erik PH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134019/
https://www.ncbi.nlm.nih.gov/pubmed/25143710
http://dx.doi.org/10.2147/DDDT.S68020
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author de Leeuw, Erik PH
author_facet de Leeuw, Erik PH
author_sort de Leeuw, Erik PH
collection PubMed
description OBJECTIVE: To test the activity of a small molecule compound that targets Lipid II against Acinetobacter baumannii. METHODS: Susceptibility to small molecule Lipid II inhibitor BAS00127538 was assessed using carbapenem- and colistin-resistant clinical isolates of A. baumannii. In addition, synergy between colisitin and this compound was assessed. RESULTS: Small molecule Lipid II inhibitor BAS00127538 potently acts against A. baumannii and acts synergistically with colistin. CONCLUSION: For the first time, a compound that targets Lipid II is described that acts against multi-drug resistant isolates of A. baumannii. The synergy with colistin warrants further lead development of BAS00127538.
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spelling pubmed-41340192014-08-20 Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii de Leeuw, Erik PH Drug Des Devel Ther Rapid Communication OBJECTIVE: To test the activity of a small molecule compound that targets Lipid II against Acinetobacter baumannii. METHODS: Susceptibility to small molecule Lipid II inhibitor BAS00127538 was assessed using carbapenem- and colistin-resistant clinical isolates of A. baumannii. In addition, synergy between colisitin and this compound was assessed. RESULTS: Small molecule Lipid II inhibitor BAS00127538 potently acts against A. baumannii and acts synergistically with colistin. CONCLUSION: For the first time, a compound that targets Lipid II is described that acts against multi-drug resistant isolates of A. baumannii. The synergy with colistin warrants further lead development of BAS00127538. Dove Medical Press 2014-08-08 /pmc/articles/PMC4134019/ /pubmed/25143710 http://dx.doi.org/10.2147/DDDT.S68020 Text en © 2014 de Leeuw. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Rapid Communication
de Leeuw, Erik PH
Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title_full Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title_fullStr Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title_full_unstemmed Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title_short Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
title_sort efficacy of the small molecule inhibitor of lipid ii bas00127538 against acinetobacter baumannii
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134019/
https://www.ncbi.nlm.nih.gov/pubmed/25143710
http://dx.doi.org/10.2147/DDDT.S68020
work_keys_str_mv AT deleeuwerikph efficacyofthesmallmoleculeinhibitoroflipidiibas00127538againstacinetobacterbaumannii

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