Nerve Growth Factor Mediates a Switch in Intracellular Signaling for PGE(2)-Induced Sensitization of Sensory Neurons from Protein Kinase A to Epac

We examined whether nerve growth factor (NGF), an inflammatory mediator that contributes to chronic hypersensitivity, alters the intracellular signaling that mediates the sensitizing actions of PGE(2) from activation of protein kinase A (PKA) to exchange proteins directly activated by cAMP (Epacs)....

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Detalles Bibliográficos
Autores principales: Vasko, Michael R., Habashy Malty, Ramy, Guo, Chunlu, Duarte, Djane B., Zhang, Yihong, Nicol, Grant D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134201/
https://www.ncbi.nlm.nih.gov/pubmed/25126967
http://dx.doi.org/10.1371/journal.pone.0104529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134201/
https://www.ncbi.nlm.nih.gov/pubmed/25126967
http://dx.doi.org/10.1371/journal.pone.0104529

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