Metformin Protects Cardiomyocyte from Doxorubicin Induced Cytotoxicity through an AMP-Activated Protein Kinase Dependent Signaling Pathway: An In Vitro Study

Doxorubicin (Dox) is one of the most widely used antitumor drugs, but its cumulative cardiotoxicity have been major concerns in cancer therapeutic practice for decades. Recent studies established that metformin (Met), an oral anti-diabetic drug, provides protective effects in Dox-induced cardiotoxic...

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Detalles Bibliográficos
Autores principales: Kobashigawa, Laura C., Xu, Yan Chun, Padbury, James F., Tseng, Yi-Tang, Yano, Naohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134245/
https://www.ncbi.nlm.nih.gov/pubmed/25127116
http://dx.doi.org/10.1371/journal.pone.0104888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134245/
https://www.ncbi.nlm.nih.gov/pubmed/25127116
http://dx.doi.org/10.1371/journal.pone.0104888

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