Mechanism and consequences of RAF kinase activation by small-molecule inhibitors

Despite the clinical success of RAF inhibitors in BRAF-mutated melanomas, attempts to target RAF kinases in the context of RAS-driven or otherwise RAF wild-type tumours have not only been ineffective, but RAF inhibitors appear to aggravate tumorigenesis in these settings. Subsequent preclinical inve...

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Detalles Bibliográficos
Autores principales: Holderfield, M, Nagel, T E, Stuart, D D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134487/
https://www.ncbi.nlm.nih.gov/pubmed/24642617
http://dx.doi.org/10.1038/bjc.2014.139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134487/
https://www.ncbi.nlm.nih.gov/pubmed/24642617
http://dx.doi.org/10.1038/bjc.2014.139

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