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Alternative lengthening of telomeres (ALT) in cancer stem cells in vivo
Chromosome ends are protected by telomeres which prevent DNA damage response and degradation. Telomerase expression extends telomeres and inhibits DNA damage response. Telomeres are also maintained by the recombination based alternative lengthening pathway. Telomerase is believed to be the sole mech...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135038/ https://www.ncbi.nlm.nih.gov/pubmed/24531712 http://dx.doi.org/10.1038/onc.2013.603 |