Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

INTRODUCTION: Unwanted drug interactions with ionic currents in the heart can lead to an increased proarrhythmic risk to patients in the clinic. It is therefore a priority for safety pharmacology teams to detect block of cardiac ion channels, and new technologies have enabled the development of auto...

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Detalles Bibliográficos
Autores principales: Elkins, Ryan C., Davies, Mark R., Brough, Stephen J., Gavaghan, David J., Cui, Yi, Abi-Gerges, Najah, Mirams, Gary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135079/
https://www.ncbi.nlm.nih.gov/pubmed/23651875
http://dx.doi.org/10.1016/j.vascn.2013.04.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135079/
https://www.ncbi.nlm.nih.gov/pubmed/23651875
http://dx.doi.org/10.1016/j.vascn.2013.04.007

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