Cargando…
Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
INTRODUCTION: Unwanted drug interactions with ionic currents in the heart can lead to an increased proarrhythmic risk to patients in the clinic. It is therefore a priority for safety pharmacology teams to detect block of cardiac ion channels, and new technologies have enabled the development of auto...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135079/ https://www.ncbi.nlm.nih.gov/pubmed/23651875 http://dx.doi.org/10.1016/j.vascn.2013.04.007 |