Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry

[Image: see text] The synthesis of novel oxetanyl peptides, where the amide bond is replaced by a non-hydrolyzable oxetanylamine fragment, is reported. This new class of pseudo-dipeptides with the same H-bond donor/acceptor pattern found in proteins expands the repertoire of peptidomimetics.

Detalles Bibliográficos
Autores principales: McLaughlin, Martin, Yazaki, Ryo, Fessard, Thomas C., Carreira, Erick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136677/
https://www.ncbi.nlm.nih.gov/pubmed/25068485
http://dx.doi.org/10.1021/ol501590n
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author McLaughlin, Martin
Yazaki, Ryo
Fessard, Thomas C.
Carreira, Erick M.
author_facet McLaughlin, Martin
Yazaki, Ryo
Fessard, Thomas C.
Carreira, Erick M.
author_sort McLaughlin, Martin
collection PubMed
description [Image: see text] The synthesis of novel oxetanyl peptides, where the amide bond is replaced by a non-hydrolyzable oxetanylamine fragment, is reported. This new class of pseudo-dipeptides with the same H-bond donor/acceptor pattern found in proteins expands the repertoire of peptidomimetics.
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spelling pubmed-41366772015-07-28 Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry McLaughlin, Martin Yazaki, Ryo Fessard, Thomas C. Carreira, Erick M. Org Lett [Image: see text] The synthesis of novel oxetanyl peptides, where the amide bond is replaced by a non-hydrolyzable oxetanylamine fragment, is reported. This new class of pseudo-dipeptides with the same H-bond donor/acceptor pattern found in proteins expands the repertoire of peptidomimetics. American Chemical Society 2014-07-28 2014-08-15 /pmc/articles/PMC4136677/ /pubmed/25068485 http://dx.doi.org/10.1021/ol501590n Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle McLaughlin, Martin
Yazaki, Ryo
Fessard, Thomas C.
Carreira, Erick M.
Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry
title Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry
title_full Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry
title_fullStr Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry
title_full_unstemmed Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry
title_short Oxetanyl Peptides: Novel Peptidomimetic Modules for Medicinal Chemistry
title_sort oxetanyl peptides: novel peptidomimetic modules for medicinal chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136677/
https://www.ncbi.nlm.nih.gov/pubmed/25068485
http://dx.doi.org/10.1021/ol501590n
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