Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes

[Image: see text] The ubiquitin-proteasome system (UPS) is a potential pathway for therapeutic intervention for pathogens such as Plasmodium, the causative agent of malaria. However, due to the essential nature of this proteolytic pathway, proteasome inhibitors must avoid inhibition of the host enzy...

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Detalles Bibliográficos
Autores principales: Li, Hao, van der Linden, Wouter A., Verdoes, Martijn, Florea, Bogdan I., McAllister, Fiona E., Govindaswamy, Kavitha, Elias, Joshua E., Bhanot, Purnima, Overkleeft, Herman S., Bogyo, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136710/
https://www.ncbi.nlm.nih.gov/pubmed/24918547
http://dx.doi.org/10.1021/cb5001263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136710/
https://www.ncbi.nlm.nih.gov/pubmed/24918547
http://dx.doi.org/10.1021/cb5001263

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