Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8

[Image: see text] The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). Monomethylation of H4K20 has been implicated in regulating diverse biological processes including the DNA damage response. In addition to H4K20, SE...

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Detalles Bibliográficos
Autores principales: Ma, Anqi, Yu, Wenyu, Li, Fengling, Bleich, Rachel M., Herold, J. Martin, Butler, Kyle V., Norris, Jacqueline L., Korboukh, Victoria, Tripathy, Ashutosh, Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V., Vedadi, Masoud, Brown, Peter J., Jin, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136711/
https://www.ncbi.nlm.nih.gov/pubmed/25032507
http://dx.doi.org/10.1021/jm500871s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136711/
https://www.ncbi.nlm.nih.gov/pubmed/25032507
http://dx.doi.org/10.1021/jm500871s

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