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Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
[Image: see text] The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). Monomethylation of H4K20 has been implicated in regulating diverse biological processes including the DNA damage response. In addition to H4K20, SE...
Autores principales: | Ma, Anqi, Yu, Wenyu, Li, Fengling, Bleich, Rachel M., Herold, J. Martin, Butler, Kyle V., Norris, Jacqueline L., Korboukh, Victoria, Tripathy, Ashutosh, Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V., Vedadi, Masoud, Brown, Peter J., Jin, Jian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136711/ https://www.ncbi.nlm.nih.gov/pubmed/25032507 http://dx.doi.org/10.1021/jm500871s |
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