Toward Hypoxia-Selective DNA-Alkylating Agents Built by Grafting Nitrogen Mustards onto the Bioreductively Activated, Hypoxia-Selective DNA-Oxidizing Agent 3-Amino-1,2,4-benzotriazine 1,4-Dioxide (Tirapazamine)

[Image: see text] Tirapazamine (3-amino-1,2,4-benzotriazine 1,4-dioxide) is a heterocyclic di-N-oxide that undergoes enzymatic deoxygenation selectively in the oxygen-poor (hypoxic) cells found in solid tumors to generate a mono-N-oxide metabolite. This work explored the idea that the electronic cha...

Descripción completa

Detalles Bibliográficos
Autores principales: Johnson, Kevin M., Parsons, Zachary D., Barnes, Charles L., Gates, Kent S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136725/
https://www.ncbi.nlm.nih.gov/pubmed/25029663
http://dx.doi.org/10.1021/jo501252p

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136725/
https://www.ncbi.nlm.nih.gov/pubmed/25029663
http://dx.doi.org/10.1021/jo501252p

Ejemplares similares